SynchroBio delivers advanced biophysical characterization services to assess the structure, stability, and aggregation of biologics, mRNA, and gene therapy products. Our biophysical assays provide essential insights for early-stage developability, formulation optimization, and regulatory comparability studies.

Key Capabilities:

• Circular dichroism (CD) – Secondary structure and conformational analysis

• Differential scanning calorimetry (DSC) and Differential scanning fluorimetry (DSF) – Thermal stability profiling

• Analytical ultracentrifugation (AUC) – Sedimentation and molecular size analysis

• Dynamic light scattering (DLS) and Multi-angle light scattering (MALS) – Particle size distribution and aggregation

• Micro-Flow Imaging (MFI) and Light Obscuration (LO) – Subvisible particle detection and quantification

• Forced degradation studies – Heat, pH, oxidative, and freeze-thaw stress

• Comparability assessments – Biophysical fingerprinting across batches or process changes

Our integrated biophysical platform supports high-resolution characterization from discovery through CMC, enabling confident decisions in drug development and regulatory submission.