Comprehensively confirm protein sequence and identify post-translational modifications.

Using LC-MS/MS peptide mapping, we identify key quality attributes, detect low-level sequence variants, and map PTMs including oxidation, deamidation, glycosylation, and phosphorylation—essential for biosimilar comparability and IND filings.

Service Includes:

• Protein digestion with multiple proteases (as needed)

• LC-MS/MS on Orbitrap Lumos

• Sequence coverage validation

• PTM mapping and quantification

• Final report with annotated spectra and findings

Turnaround Time: 10–15 business days
Sample Requirements: ≥100 µg purified protein
Add-ons: Glycopeptide mapping, forced degradation comparison